diff --git a/cargo/private/cargo_build_script.bzl b/cargo/private/cargo_build_script.bzl
--- a/cargo/private/cargo_build_script.bzl
+++ b/cargo/private/cargo_build_script.bzl
@@ -120,6 +120,44 @@
     executable = True,
 )
 
+def _rewrite_windows_exec_msvc_cc_args(toolchain, args):
+    """Translate GNU-flavored cc args when exec-side build scripts target Windows MSVC."""
+    if toolchain.target_flag_value != toolchain.exec_triple.str or not toolchain.exec_triple.str.endswith("-pc-windows-msvc"):
+        return args
+
+    rewritten = []
+    skip_next = False
+    for arg in args:
+        if skip_next:
+            skip_next = False
+            continue
+
+        if arg == "-target":
+            skip_next = True
+            continue
+
+        if arg.startswith("-target=") or arg.startswith("--target="):
+            continue
+
+        if arg == "-nostdlibinc" or arg.startswith("--sysroot"):
+            continue
+
+        if "mingw-w64-" in arg or "mingw_import_libraries_directory" in arg or "mingw_crt_library_search_directory" in arg:
+            continue
+
+        if arg.startswith("-fstack-protector"):
+            continue
+
+        if arg.startswith("-D_FORTIFY_SOURCE="):
+            continue
+
+        rewritten.append(arg)
+
+    return [
+        "-target",
+        toolchain.target_flag_value,
+    ] + rewritten
+
 def get_cc_compile_args_and_env(cc_toolchain, feature_configuration):
     """Gather cc environment variables from the given `cc_toolchain`
 
@@ -503,6 +541,8 @@
         if not env["AR"]:
             env["AR"] = cc_toolchain.ar_executable
 
+        cc_c_args = _rewrite_windows_exec_msvc_cc_args(toolchain, cc_c_args)
+        cc_cxx_args = _rewrite_windows_exec_msvc_cc_args(toolchain, cc_cxx_args)
         # Populate CFLAGS and CXXFLAGS that cc-rs relies on when building from source, in particular
         # to determine the deployment target when building for apple platforms (`macosx-version-min`
         # for example, itself derived from the `macos_minimum_os` Bazel argument).